Pfizer-BioNTech Booster Shot may provide better immunity than a double dose regimen

new medRxiv * Preprint studies suggest that the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is greater in the triple-dose regimen than in the double-dose regimen. Administration of Pfizer-BioNTech booster shot increased IgG levels one month after the second dose by 1.7-fold compared to IgG levels one month after the second dose.In addition, there was a significant 6.1-fold increase. Neutralizing antibody ..

Booster shots have produced a high immune response between healthcare professionals over the age of 60 and people with two or more comorbidities. Booster shots showed 85.6% vaccine efficacy compared to the first two Pfizer-BioNTech doses. The researchers conclude that the third dose of Pfizer-BioNTech is immunologically “better” than the second dose. Booster shots have shown considerable effect on newly identified Omicron variants that have caused record numbers of breakthrough infections in vaccinated individuals. In addition, booster shots may be essential in providing protection for the elderly or immunocompromised people who may not have a complete antibody response on the first two doses. How they did it

The researchers studied the vaccine efficacy, vaccine safety, and immune response of 12,413 healthcare workers in Israel who received a third dose of the Pfizer-BioNTech vaccine.

Serum samples were collected from healthcare workers vaccinated after the second dose, before the third dose, and after the third dose to study changes in antibody levels. Vaccine efficacy was studied among health care workers who vaccinated two vaccines three times at least five months ago.

Heathcare workers vaccinated with booster shots by September 2, 2021 were invited to complete an electronic questionnaire containing post-vaccination adverse events. The third Pfizer-BioNTech shot boosts immunity to SARS-CoV-2

The third dose of vaccine increased IgG antibody levels 31-fold compared to the second dose. In addition, the neutralizing antibody increased 41-fold after the third dose.

Researchers have also found a small but significant increase. T cells Revitalization of 16 healthcare workers. The average IgG titer was higher after the third (2,745) than at the second (1,586). In other words, a 1.7-fold increase in IgG levels was observed after the third booster shot. On the third dose, the neutralizing antibody increased from 646 to 3,948. This was converted to a 6.1-fold increase from the second dose.

Researchers also tested antibody binding strength to the complex antigen After the second and third doses. The second dose gave 61.1% antibody binding strength and the third dose gave 96.3% binding strength. Age did not make a difference in bond strength between doses. Individual factors related to dose strength

Old age was associated with decreased IgG levels and neutralization of titers after the second dose. Being a man and having one or two existing health conditions was also associated with lower levels.

The higher IgG layer correlates with obesity (BMI greater than 30) than the non-higher IgG layer. In healthcare professionals over the age of 60 with two or more comorbidities, the third dose increased IgG antibody levels 1.41-fold. In addition, the neutralizing titer of this age group increased 1.66 times compared to younger health workers […]

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